BTB: BTB/POZ domain
| PAG Title | BTB: BTB/POZ domain |
| PAG ID | PEX000443 |
| Type | A |
| Source Link |  Pfam |
| Publication Reference | NA |
| PAG Description | The BTB (for BR-C, ttk and bab) 1 or POZ (for Pox virus and Zinc finger) 2 domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation 2. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule 3. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT 4,5,6. The POZ or BTB domain is also known as BR-C/Ttk or ZiN. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 0 |
| Information Content | Poor |
| Other IDs | PF00651 |
| Base PAG ID | PEX000443 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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